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RETICULUM-ASSOCIATED DEGRADATION, ENDOPLASMIC
Descriptors Found:
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DeCS
Descriptor
English
:
Endoplasmic Reticulum-Associated Degradation
Descriptor
Spanish
:
Degradación Asociada con el Retículo Endoplásmico
Descriptor
Portuguese
:
Degradação Associada com o Retículo Endoplasmático
Synonyms
English
:
Degradation, Endoplasmic Reticulum-Associated
ERAD Pathway
ERAD Pathways
Endoplasmic Reticulum Associated Degradation
Pathway, ERAD
Pathways, ERAD
Reticulum-Associated Degradation, Endoplasmic
Tree Number:
G02.111.660.871.790.600.962.500
G02.111.691.600.850.500
G03.734.871.790.600.850.500
G05.308.670.600.850.500
Definition
English
:
A degradation process whereby incorrectly folded
proteins
are selectively transported out of the
ENDOPLASMIC RETICULUM
and into the
CYTOSOL
. The misfolded
proteins
are subsequently ubiquitinated and degraded by the PROTEASOME.
See Related
English
:
Endoplasmic Reticulum Stress
Proteolysis
Ubiquitination
History Note
English
:
2012
Allowable Qualifiers
English
:
DE
drug effects
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects
Record Number:
54774
Unique Identifier:
D060746
Occurrence in VHL
:
Similar:
DeCS